INFIQC   05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems
Autor/es:
VERÓNICA BRUNETTI; LYDIA BOUCHET; MIRIAM STRUMIA
Revista:
Nanoscale
Editorial:
Royal Society
Referencias:
Año: 2015 vol. 7 p. 3808 - 3816
ISSN:
2040-3372
Resumen:
Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules. This kind of hybrid nanocomposite aims to combine the advantages of stimuliresponsive dendritic coatings, in order to regulate the drug release behaviour under different conditions and improve the biocompatibility and in vivo half-time circulation of the inorganic nanoparticles. Size, surface chemistry and shape are key nanocarrier properties to evaluate. Here, we have reviewed the most recent advances of NCDs in drug delivery systems, compared their behaviour with non-dendritic stabilized nanoparticles and highlighted their challenges and promising applications in the future