Toxicological study employing repeated doses of Garcinielliptone FC, a polyisoprenylated benzophenone isolated from seed of Platonia insignis Mart

ANA P. SILVA; JOSÉ CARLOS C. L. S. FILHO; JOAQUIM S. DA COSTA JÚNIOR; WALTER J. PELÁEZ; MARTÍN S. FAILLACE; ALEXANDRE DE B. FALCÃO FERRAZ; JORGE M. DAVID; RIVELILSON M. FREITAS

JOURNAL OF PHARMACY AND PHARMACOLOGY

PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN

Año: 2015 vol. 3 p. 316 - 330

0022-3573

The major constituent from the hexane extract of the seeds of P. insignisis GFC (garcinielliptone FC). Doses of 25, 50 and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline (vehicle) and orally administered for30, 90 and 120 consecutive days to adult Swiss mice. In this work, the repeated oral administration, in animals of both sexes, demonstrates that this compound is not able to induce mortality and/or behavioral changes in adult mice. In addition, body weight gain, feed intake and disposal of excreta were not altered by the administration of this compound with repeated doses. Furthermore, no differences in weight and macroscopic structure of the brain,liver, kidney, lung, heart and spleen between groups of male and female adult mice were observed after treatment. During the periods of treatment, GFC produced no significant changes on haematological and biochemical parameters in male and female mice treated with all doses used. The aim of this study was to investigate the toxicological potential of GFC through behavioral, hematological, biochemical and morphological parameters in animals in order to ensure the safe use of Platonia insignisin folk medicine.