One-pot synthesis of 3-substituted isoquinolin-1-(2H)-ones and fused isoquinolin-1-(2H)-ones by S(RN)1 reactions in DMSO

GUASTAVINO,J.F.; BAROLO,S.M.; ROSSI,R.A.

Eur. J. Org. Chem.

Año: 2006 p. 3898 - 3902

1434-193X

3-Substituted isoquinolin-1-(2H)-ones and fused isoquinolin-1-(2H)- ones have been obtained by the photostimulated S(RN)1 reactions of 2- iodobenzamide with the enolates of aromatic (acetophenone, 1- (benzo[d][1,3]dioxol-5-yl)ethanone, 1- and 2-naphthyl methyl ketones, and 2-, 3-, and 4-acetyl-pyridine), aliphatic (1-adamantyl methyl ketone), and cyclic ketones (1- and 2-indanone, alpha- and beta- tetralone, and 1-benzosuberone) in DMSO.