INFIQC 05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Novel synthesis of 2-thienylcarbonyl-cyclohexane-1,3-dione as building block for indazolones and isoxazolones
Autor/es:
GUILLERMO M. CHANS; ELIZABETH L. MOYANO; GLORIA I. YRANZO
Revista:
AUSTRALIAN JOURNAL OF CHEMISTRY
Editorial:
CSIRO PUBLISHING
Referencias:
Lugar: Collingwood; Año: 2011 vol. 64 p. 638 - 646
ISSN:
0004-9425
Resumen:
A new synthetic methodology using ultrasonic treatment was applied to the C-acylation of 1,3-cyclohexanedione with thiophene-2-carbonyl-chloride to afford 3-hydroxy-2-(2-thienylcarbonyl)cyclohex-2-en-1-one (5). This compound was used as building block to prepare different bicyclic systems: tetrahydro-4H-indazol-4-ones (7a-c and 9a,b,d), and 6,7-dihydrobenzisoxazole (11) by reactions with different hydrazines and hydroxylamine respectively. Structural elucidation of all compounds was thoroughly achieved by NMR spectroscopy.
