INFIQC 05475
INSTITUTO DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans.
Autor/es:
TOMAS C. TEMPESTI; M. GABRIELA ALVAREZ; MARCELO FRANCISCO DE ARAÚJO; FRANCISCO EDUARDO ARAGÃO CATUNDA JÚNIOR; MÁRIO GERALDO DE CARVALHO; EDGARDO N. DURANTINI
Revista:
MEDICINAL CHEMISTRY RESEARCH
Editorial:
BIRKHAUSER BOSTON INC
Referencias:
Lugar: Boston; Año: 2011
ISSN:
1054-2523
Resumen:
In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.
