Evaluation of the ejaculatory activity produced by Satureja parvifolia (Phil.) Epling

BRUENNER SOFÍA; VALLEJO MARIANA; HERNANDEZ FERNANDO; CARRO-JUÁREZ MIGUEL; BIRRI MARCELA; AGNESE ALICIA MARIEL

Buenos Aires

Congreso; XLIX REUNIÓN ANUAL SAFE - REUNIÓN CONJUNTA SOCIEDADES DE BIOCIENCIAS; 2017

Sociedad Argentina de Farmacología Experimental y Sociedades de Biociencias

Continuing with the studies on aphrodisiac plants, we worked in this occasion with Satureja parvifolia (Phil.) Epling (Lamiaceae). Very well known, especially in the north of Argentina, the ?muña-muña? is reputed in the ethnomedicine as an aphrodisiac. So far, it lacks scientific studies related to this effect. The objective of the present work was to evaluate the infusion of the species in the Fictive Ejaculation Model. It is known that the ejaculatory response is regulated by the CNS at both, the spinal and brain levels. This model allows the experiment to become independent of the brain to evaluate the effect of a particular substance on the Spinal Generator of Ejaculation. We worked with male Wistar rats trained in sexual behavior until being considered sexually expert. The animals were divided according to the Latency of Ejaculation (LE) in premature (those with LE ≤ 10 minutes) and intermediate (LE ≤ 20 minutes). Premature rats were selected. They were anesthetized and submitted to surgery to section the spinal cord at the level of the T6 vertebra, above the Spinal Generator. The animals were divided into 3 groups, of three animals each. Physiological solution (Control Group) or infusion of S. parvifolia (Treatment groups) were administered intravenously in doses of 10 and 30 μg/kg. The results showed that the infusion at 10 μg/kg facilitates ejaculation in premature rats producing an increase in the Number of Discharges (ND, number of contractions of the bulbospongiosus muscles) (P