Photoinactivation of Leishmania amazonesis by natural anthraquinones

DIMMER JJ; NÚÑEZ MONTOYA SC; SABINO CP; RIBEIRO MS; CABRAL FV; CABRERA JL

Coimbra

Congreso; 16th INTERNATIONAL PHOTODYNAMIC THERAPY WORLD CONGRESS; 2017

Chemistry Department, University of Coimbra

Cutaneous leishmaniasis is a clinical form of a parasitic disease characterized by developing skin lesions with raised borders, eventually ulcerated, and limited to a specific area.1 The potential toxicity as well as the increased resistance of standard treatments have led to development of alternative medication. Antimicrobial photodynamic therapy appears as an alternative treatment for localized infections caused by microorganisms.2Our research group has succeeded in the isolation of several anthraquinones (AQs) obtained from H. lycioides with good photosensitizing properties.3 The aim of this work was to study the photoinactivation of Leishmania amazonensis by using soranjidiol (sor) and derivatives structures: 5-chlorosoranjidiol (5-clsor), bisoranjidiol (bis), 7-chlorobisoranjidiol (7-clbis) y lycionine (lyc).