IMBIV   05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Natural photosensitizer and their potential application in photodynamic antimicrobial chemotherapy
Autor/es:
JELICICH N; ESTRABOU C; NÚÑEZ MONTOYA SC; PAEZ P; COMINI LR ; RODRIGUEZ JM; CABRERA JL
Lugar:
Santiago
Reunión:
Encuentro; 25th INTER-AMERICAN PHOTOCHEMICAL SOCIETY MEETING; 2016
Institución organizadora:
IAPS, Univer. Católica de Chile
Resumen:
The photodynamic antimicrobial chemotherapy (PACT) involves the use of photosensitizers and visible or ultraviolet light in the treatment of local infections, especially caries, periodontal diseases, oral candidiosis as well as infected wounds. Some photosensitizers, like the psoralen derivatives, produce bacterial photoinactivation by a mechanism that allows their intercalation between the nucleic acid bases. Others have the same final output, but this is reached by means of a photodynamic photosensitization, in which the generation of reactive oxygen species (ROS) is the main process. Within the photodynamic mechanism, it is worth mentioning that several anthraquinones (AQs) have been thoroughly studied in relation to their photosensitizing properties. Thus, for instance, some of them show good antibacterial effects by producing ROS, such as superoxide anion (O2?_; photodynamic reaction Type I) and singlet molecular oxygen (1O2; photodynamic reaction Type II), generating a photosensitized cellular inactivation. In this context, we started the phytochemical study of the lichen Teleoschistes flavicans (SW) Norm. (Telochistaceae), which revealed the presence of Parietin (PTN). By mean of photochemical and photobiological studies, we have previously demonstrated that this AQ is an excellent photosensitizer Type I and II.