IMBIV   05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Poly(NIPA-co-AAc) nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems for cancer therapies
Autor/es:
J. C. CUGGINO; M. A. MOLINA ; S. WEDEPOHL; ALVAREZ IGARZABAL, CECILIA INES; M. CALDERON; L. M. GUGLIOTTA
Lugar:
Santa Fe
Reunión:
Simposio; XI Simposio Argentino de Polímeros; 2015
Institución organizadora:
Sociedad Argentina de Polimeros
Resumen:
Various poly(N-isopropylacrylamide-co-acrylic acid) (NIPA-co-AAc) nanogels (NGs) with different NIPA/AAc molar composition were synthesized by precipitation/dispersion polymerization and evaluated as carriers for drug delivery systems (DDSs) of doxorubicin hydrochloride (DOXO·HCl) forcancer therapies. The prepared NGs presented excellent dispersability in a simulated physiological environment (pHs: 7.4 and 5, at 37 °C), as shown by dynamic light scattering (DLS). Moreover, the NGs exhibited high drug loading capacity and efficiency due to the ionic interaction of the cationic drug withthe anionic NGs. The NG-DOXO·HCl formulation presented excellent dispersability in water and minimal leakage of the cargo at plasma simulated medium (pH 7.4 and 0.14M NaCl) at 37 °C and a triggered release of DOXO·HCl at lysosomal simulated medium (pH 5 and 0.14M NaCl). This release behavior together with their size and the low cytotoxicity determined by the MTT assay makes these NGsgreat candidates for their application as carriers in cancer therapies based on the enhanced permeability and retention effect (EPR) with drug pH-triggered release after endocytosis in tumor cells sites.