Green Analysis of the Bromination Reaction of Propiophenone Derivatives Mediated by Cu 2+ Complexes

ROSSI., LAURA I.; KRAPACHER, CLAUDIO R.

ChemistrySelect

Wiley-Blackwell Publishing Ltd

Año: 2020 vol. 5 p. 4740 - 4747

2365-6549

All processes and reactions were evaluated using greenmetrics. Alternatives for the α-halogenation reaction of ketones were studied, varying both the methodology and the brominating reactants. CuBr2 and its complexes with organic ligands derived from biomass were used as bromide source. Distinct regioselectivity and chemoselectivity were observed with the different complexes used. The CuBr2-βCD complex behave completely different to the rest of the complexes since the halogenation occurred preferentially in the propiophenone aromatic ring. Among the complexes used, novel starch and chitosan complexes with CuBr2 were synthesized and characterized by EPR, FT-IR, UVV RD and TGA.