IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
α-amination reaction of different ketones mediated by carbohydrate Cu2+ complexes
Autor/es:
GRANADOS, ALEJANDRO M.; KRAPACHER, CLAUDIO R.; ROSSI, LAURA I.
Revista:
Molecular Catalysis
Editorial:
Elsevier BV
Referencias:
Lugar: Amsterdam; Año: 2020 vol. 493
ISSN:
2468-8231
Resumen:
The α-amination reaction of ketones was studied and the reaction conditions were analysed by green metrics. Propiophenone and two aliphatic ketones, saturated cyclic and acyclic secondary amines were used, carbohydrate Cu2+ complexes were the catalysts to obtain the brominate intermediates. Traditional stirring and ultrasound methods were compared. The use of α-CDCuBr2 complex in the presence of propiophenone, morpholine and O2 was the best condition to carry out the α-amination reaction using a One Pot synthesis, with an 80 % yield of product isolated and no by-product was detected.
