Stereochemistry Determination by Powder X-ray Diffraction Analysis and NMR Residual Dipolar Couplings

MANUELA E. GARCIA, SILVINA PAGOLA, ARMANDO NAVARRO-VÁZQUEZ, DAMILOLA D. PHILLIPS, CHAKICHERLA GAYATHRI, HENRY KRAKAUER, PETER W. STEPHENS, VIVIANA E. NICOTRA AND ROBERTO R. GIL.

Angewandte Chemie

WILEY-V C H VERLAG GMBH

Lugar: Weinheim, Germany; Año: 2009 vol. 48 p. 5670 - 5674

1433-7851

For a new steroidal lactol, jaborosalactol 24 (1), isolated from Jaborosa parviflora, NMR spectroscopy residual dipolar couplings and powder X-ray diffraction analysis independently gave the same stereochemistry at C23-C26. Conventional NMR spectroscopic techniques, such as NOE and 3J coupling-constant analysis failed to unambiguously determine this stereochemistry