IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Mild Thio-Diversification of Bioactive Natural Products. Withaferin A: A Case study
Autor/es:
PEÑÉÑORY, A.B.; GARCÍA, M.E.; BISOGNO, F.R.; OBERTI, J.C.; CASERO, C.N.; NICOTRA, V.E.; NOVILLO, J. N. GARAY
Revista:
ChemistrySelect
Editorial:
Wiley-Blackwell
Referencias:
Año: 2017 vol. 2 p. 10470 - 10475
ISSN:
2365-6549
Resumen:
A sustainable strategy was developed to create chemical diversity from bioactive scaffolds. The methodology comprises a set of simple reactions between the parent compound (i. e. withaferin A), and small sulfur nucleophiles in hydroalcoholic media, at room temperature and in open-air atmosphere. Novel steroidal sulfur natural product-analogs were obtained, featuring ring opening, ring formation, new stereocenters and modulation of parameters useful in medicinal chemistry.
