IMBIV   05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Sauroine, an Alkaloid from Huperzia saururus with Activity in Wistar Rats in Electrophysiological and Behavioral Assays related to Memory Retention.
Autor/es:
MARIANA G. VALLEJO; MARÍA G. ORTEGA,; JOSÉ L. CABRERA; VALERIA P. CARLINI,; SUSANA RUBIALES DE BARIOGLIO; ROMINA S. ALMIRÓN, ,; OSCAR A. RAMÍREZ; ALICIA AGNESE
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
ACS Publications
Referencias:
Año: 2009 vol. 72 p. 156 - 158
ISSN:
0163-3864
Resumen:
The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.