IMBIV   05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis
Autor/es:
VENUGOPALA K.N.; PADMASHALI B.; ODHAV B.; GLEISER R.M.; KULKARNI R.S.; SANDEEP, C.; CHETRAM A.; VENUGOPALA R.
Revista:
CHEMICAL BIOLOGY & DRUG DESIGN
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2016 vol. 88 p. 899 - 904
ISSN:
1747-0277
Resumen:
Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron-deficient alkynes in the presence of water as the base and solvent at 80°C. Yield of the title compounds was good and reactions performed were ecofriendly. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques such as FTIR, NMR, LC-MS, and elemental analysis. Characterized title compounds were evaluated for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using Temefos as standard at 4μg/mL. Title compounds 2e, 2f, and 2g emerged as promising larvicidal agents