IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
First generation newkome-type dendrimer as solubility enhancer 3 of antitumor benzimidazole carbamate
Autor/es:
NAHIR DIB; LUCIANA FERNANDEZ; LUIS OTTERO; MARISA SANTO; MARCELO CALDERÓN; MARISA MARTINELLI; MIRIAM C. STRUMIA
Revista:
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2015 vol. 82 p. 351 - 359
ISSN:
0923-0750
Resumen:
A first generation dendrimer was evaluated as solubility enhancer of the antitumor compound methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate. The dendrimer possess carboxylic acid as terminal groups, which provide high water solubility and a low cytotoxic character. The drug-dendrimer association significantly increases active compound solubility in water, avoiding aggregation. The formulation is stable several weeks in a wide temperature range. The formation of Langmuir monolayers in air-water interface of dendrimer-active compund blends evinces the viability of the complex to generate films for surface-mediated drug delivery systems.
