IMBIV   05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Synthesis of macroporous polymers with radical scavenging properties by immobilization of polyphenolic compounds
Autor/es:
R. DARIO ARRUA; JUAN F. BASBUS; MIRIAM C. STRUMIA; ALVAREZ IGARZABAL, CECILIA I.,; MÓNICA A. NAZARENO
Revista:
REACTIVE & FUNCTIONAL POLYMERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 72 p. 807 - 813
ISSN:
1381-5148
Resumen:
Solid phase radical scavengers have been prepared by the immobilization of antioxidant (AOX) compounds on macroporous polymers. Poly(glycidylmethacrylate-co-trimethylolpropane trimethacrylate) [poly(GMA?TRIM)] and poly(N-acryloyl-tris(hydroxymethyl)aminomethane-co-glycidylmethacrylateco- N,N0-methylenebisacrylamide) [poly(NAT?GMA?BIS)] were prepared by free radical polymerization using a mixture of dimethylsulfoxide (DMSO)-poly(ethyleneglycol) 6000 (PEG 6000) as a porogenic solvent. The polymers were aminated with ethylenediamine (EDA) and the linkage of the polyphenolic compounds(gallic and caffeic acids) was carried out by two different approaches: through N,N0-dicyclohexylcarbodiimide/4-dimethylaminepyridine (DCC/DMAP) system (one-step method) or through the previous formation of the acyl chloride of the polyphenolic compounds and subsequent amidation reaction (two-step method). The available phenolic groups on the macroporous polymers were determined using the Folin?Ciocalteu method; the radical scavenging properties of the materials prepared were evaluated using the radical species 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,20-azinobis-[3-ethylbenzothiazoline-6-sulfonic acid] radical cation (ABTS+). From the results, higher antiradical capacities were obtained with the polymers in which the immobilization of the antioxidant molecules was performed through the two-step method. The polymeric networks prepared in this work yielded up to 13.2 lmol AOX/g of dry polymer, which allowed a quantitative removal of the radicals tested in less than 30 min.