ERα expression is associated to antitumoral activity of chia oil enriched diet

VARA MESLER M; PASQUALINI M E; COMBA A; BUCCELLATI C; TRENTI A; TREVISI L; EYNARD AR; SALA A; BOLEGO C; VALENTICH MA

Stockholm

Congreso; 11th Congress of the Internacional Society for the Study of Fatty Acids and Lipids; 2014

INTERNATIONAL SOCIETY FOR THE STUDY OF FATTY ACIDS AND LIPIDS (ISSFAL)

Mammary gland adenocarcinoma (MGA) is the most common tumour where estrogen receptor (ER) plays a key role. ERα promotes tumour growth, while ERβ has an anti-proliferative effect. Chia oil is rich in α-linolenic acid (ALA 18:3 ω-3), while corn oil is rich in linoleic acid (LA 18:2 ω-6). ALA and LA are precursors of eicosanoid with opposite effects in BC and also generate reactive oxygen species (ROS), which could affect NF-κB. The study was aimed to determine possible mechanisms that are activated by dietary lipids regulating MGA growth. BALB/c mice were fed with a diet rich in Chia Oil (ChO) or Corn Oil (CO) and inoculated with LM3, a MGA murine cell line. After 35 days tumour incidence was higher in CO-fed mice compared with ChO-fed mice (100 vs 85%, p