CIQUIBIC 05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Surface Properties of Insulin-DPPC/POPC mixed Langmuir monolayers.
Autor/es:
GRASSO EJ; OLIVEIRA RG; MAGGIO B
Lugar:
Sierra de la Ventana
Reunión:
Congreso; XLIII Reunión Anual de la Sociedad Argentina de Biofísica; 2014
Institución organizadora:
Sociedad Argentina de Biofísica
Resumen:
The surface properties of the binary mixed Langmuir monolayers ofInsulin and DPPC (dipalmitoylphosphatidylcholine) and POCP(palmitoyloleylphosphatidylcholine) spread at the air-waterinterface was studied. Pure and mixed monolayers were spread onZn2+ containing solutions. Miscibility and interactions between thecomponents were studied on the basis of the analysis of thesurface pressure-mean molecular area isotherms, surfacecompressional modulus and plots of mean molecular area andsurface potential versus mole fraction of Insulin. Our resultsindicate that the intermolecular interactions between Insulin andDPPC/POPC depend on both the monolayer state and thestructural characteristics of Insulin at the interface, which isstrongly influenced by the Zn2+ ions in the subphase (1). Brewsterangle microscopy was applied to describe the surface topographyof the monolayers. We concluded that Insulin forms mixed surfaceswith DPPC/POPC at all the mole fraction studied.1 Grasso EJ et al. Colloids and Surfaces B. 2014, 219.
