CIQUIBIC   05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
?Study of the structure and dynamics of domains in lipid monolayers with phase coexistence?
Autor/es:
RUFEIL FIORE N, N. WILKE, BANCHIO A.
Lugar:
Bariloche
Reunión:
Encuentro; ´XIV Encuentro de superficies y materiales nanoestructurados´; 2014
Resumen:
in a condensed phase state dispersed in a continuous
liquid-expanded phase. Simple and wide used models for biological membranes are
the Langmuir monolayers, which have the possibility to change their composition
and phase state in a very controlled manner.
For neutral
lipids, the interdomain interactions are of dipolar nature. ``Usually'' domains
are modeled as point dipoles with excluded area interactions. This
approximation disregards the fact that the ``effective'' dipolar interaction
arises from the dipolar surface densities carried by the lipids inside the domains,
and thus is a good model only for large interdomain distances and small domains.
In this work we investigated the structure, dynamics and
rheology of inhomogeneous monolayer at the air/water interface. For this
purpose we implemented brownian dynamics simulations taking into account the
surface dipolar density interactions, and we performed experiments with mixed
monolayers at different proportions of distearoylphosphatidylcholine (DSPC) and
dimyristoylphosphatidylcholine (DMPC).
We studied the
pair correlation function, self-diffusion coefficient and surface shear
viscosity as a function of the condensed area fraction, and the range validity
of the point dipole approximation.