Effect of polymerics dendrons on membranes models

M. SASSI; C. I. CÁMARA; L. M. YUDI; A. V. JUAREZ

Sierra de la Ventana - Buenos Aires

Congreso; Sociedad Argentina de Biofísica. XLIII Reunión Anual 2014; 2014

Sociedad Argentina de Biofísica

Dendritic molecules are extensively used as nanoscopic auxiliaries for the constructions of dendronized polymers, macromonomers or for the dendronization of other materials or surfaces. With the increasing interest in dendritic chemistry, it is important to develop suitable methods to characterize their properties. Our particular interest is the characterization of dendronized polymers. The dendron employed in this work, aminotriester (AT), was used to modify chitosan and this change in the chemical structure confers new properties to the polymer. The main interest in this kind of macromolecules is based on the multiplicity of functional groups which enhance the bio-recognition when they are employed as pharmaceutical drugs carriers for controlled delivery. The main objective of this work is to study the effect of aminotriester in the compactness and permeability of lipids monolayer. This study can contribute to the characterization of the behaviors of these molecules in biological environments. In this work we study the interaction of 1,2-dilauroyl-sn-glycero-3-phosphate (sodium salt) (DLPA) and distearoyl phosphatidic acid (DSPA) with the dendritic molecule AT present at different concentrations. For both phospholipids monolayers analyzed, an expansion effect in the isotherm was observed due to the presence of AT between the lipids molecules.