CIQUIBIC   05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
The Immediate Early Oncopreoteins Fra-1, c-Fos and c-Jun have indistinguishable Surface Behaviour and Interactions with Phospholipids
Autor/es:
GAGGIOTTI MC; DEL BOCA M; CASTRO G; CAPUTTO BL; BORIOLI GA,
Revista:
BIOPOLYMERS
Editorial:
John Wiley and Sons
Referencias:
Lugar: Hoboken, New Jersey; Año: 2008
ISSN:
0006-3525
Resumen:
This work explores the surface properties of the
transcription factor Fra-1 and compares them with those
of two other immediate early proteins, c-Fos and c-Jun, to
establish generalities and differences in the surface
behavior and interaction with phospholipids of this type
of proteins. We present several experimental clues of the
flexible nature of Fra-1, c-Fos, and c-Jun that support
sequence-based predictions of their intrinsical disorder.
The values of surface parameters for Fra-1 are similar in
general to those of c-Fos and c-Jun. However, we find
differences in the interactions of the three proteins with
phospholipids. The closely related Fra-1 and c-Fos share
affinity for anionic lipids but the former has more affinity
for a condensed phase and senses a change in DPPC
phase, while the latter has more affinity for an expanded
phase. These features are in contrast with our previous
finding that c-Jun is not selective for phospholipid polar
head group or charge. We show here that at least some
immediate early transcription factors can interact with
membrane phospholipids in a distinguishable manner,
and this shall provide a basis for their potential capacity
to regulate membrane-mediated cellular processes.