CIQUIBIC   05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Importance of Lipid Composition in the Membrane Dynamics of Urothelial Umbrella Cells
Autor/es:
GRASSO EJ
Revista:
AASCIT communications
Editorial:
New Castle, DE : American Association for Science and Technology
Referencias:
Año: 2014 vol. 1 p. 44 - 47
ISSN:
2375-3803
Resumen:
The studies on membrane dynamics in urinary bladder umbrella cells were
focused on proteins as important factors for maintaining the permeability
barrier and their role as pathways modulators for the discoidal/fusiform
endocytic vesicles which is one of the main features of the umbrella cells. However,
our workgroup has dedicated to the study of lipid membrane composition and its
biological impact in the urothelium. We first studied the lipid membrane
composition of rat urothelium modified my dietary treatments differentiated in
their fatty acid composition. Changes of lipid composition were related to the
asymmetric unit membrane organization and permeability. Finally, we observed that the lipid
composition was critically related to the intracellular pathways of
discoidal/fusiform endocytic vesicles and their content. The purpose of this
communication is to summarize the importance of lipids in the membrane
organization and permeability of the apical plasma membrane and endocytic
vesicles of umbrella cells.