CIQUIBIC 05472
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity.
Autor/es:
SOSA L., DUPRAZ S., LAURINO .L, BOLLATI F., BISBAL M., CACERES A., PFENNINGER K.H., QUIROGA S.
Revista:
NATURE NEUROSCIENCE.
Referencias:
Año: 2006 vol. 9 p. 993 - 995
ISSN:
1097-6256
Resumen:
ABSTRACT
How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and a siRNA targeting the IGF-1 receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the PI3k-Cdc42 pathway by the IGF-1 receptor, but not by the receptors TrkA or B.
