The effect of mono- or biparental care on ethanol-induced locomotor stimulation in C57BL/6 mice

MOLINA JC; MOLINA JC; MIRANDA MORALES RS; MIRANDA MORALES RS; GUTTLEIN L; GUTTLEIN L

Puerto Varas

Congreso; VIII LASBRA International Meeting: ?Neurobiological basis of alcoholism: from molecules to behavior?; 2017

LASBRA

THE EFFECT OF MONO- OR BIPARENTAL CARE ON ETHANOL-INDUCED LOCOMOTOR STIMULATION IN C57BL/6 MICE.Miranda Morales, R.S. 1,2; Guttlein, L.1; Molina, J.C. 1,21 Instituto M. M. Ferreyra, INMEC-CONICET-UNC. Córdoba, 5000, Argentina 2 Facultad de Psicología, Universidad Nacional de Córdoba. Córdoba, 5000, Argentina.E-mail: smiranda@immf.uncor.edu Social attachment plays an important role in progeny development. Different social experiences during early development and throughout life can affect ethanol use and abuse. In the present study we aimed to analyze if different rearing conditions (mono- or biparental care), in a non-monogamous mice strain, are able to modify ethanol-induced locomotor stimulation. This effect induced by psychoactive drugs has been considered an index of positive rewarding effects of the drug. C57BL/6 infant mice were reared in a monoparental (MP, only mother) or biparental (BP, father and mother) care condition. At postnatal days (PD) 16, 17, 18 and 20, infants were administered with a 0.0 or 2.0 g/kg ethanol dose and evaluated in an open field test. Results indicate that both groups are sensitive to ethanol stimulating effects. MP animals showed tolerance to ethanol-induced stimulation since PD17. Nevertheless, BP animals did not show tolerance to ethanol effect even after the four days of test. Moreover, the intensity of this ethanol effect was also more robust in BP than MP infants. These results indicate that presence of the father in a non-monogamous strain alter ethanol rewarding effects. Further research is being conducted aimed to analyze parents? behavior during this sensitive period.