Efectos de escopolamina y propranolol sobre un tratamiento que facilita la recuperacion de la frustracion

JUSTEL N; PAUTASSI R.M.; PSYRDELLIS M

Buenos Aires

Congreso; VIII Congreso Internacional de Investigación y Práctica Profesional en Psicología, XXIII Jornadas de Investigación y XII Encuentro de Investigadores en Psicología del MERCOSUR; 2016

UBA

Frustration can be defined as an emotional state generated by the omission or devaluation in the quantity or quality of an expected appetitive reward. This phenomenon is known as incentive relativity, and can be studied by successive negative contrast (cSNC: a sudden shift from a highly appetitive reward, 32% sucrose solution, to a less preferred one, 4% sucrose solution). The exploration of a novel open field (OF) is a complex situation that involves several behavioral processes, including stress induction and novelty detection. OF exposure can enhance or block the acquisition of associative and non-associative memories. The central cholinergic and noradrenergic systems have been implicated in learning, memory processes and in the modulation of novelty-induced arousal . These experiments evaluated the effect of OF exploration after the acquisition of the downshifted memory on frustration (Experiment 1) and the role played by the cholinergic (Experiment 2) and noradrenergic (Experiment 3) systems in this phenomenon. Subjects: ♂ Wistar rats, individually housed with unrestricted access to tap water and kept at 85% of their ad libitum weight.cSNC: Rats were exposed to a 32% sucrose solution in MED boxes for 5 trials, and then shifted to 4% sucrose for 3 trials. Open Field: Free exploration of an open field (OF) for 5 min or remaining in the home cage. Dependent Measure: Goal tracking time (s)Drug: Scopolamine (SCOP, cholinergic antagonist, 1.0mg/kg), Propranolol (PROP, noradrenergyc antagonist, 4.5mg/kg) or vehicle (saline), vol.: 1.0 ml/kg, administered intraperitoneally after OF exploration. Statistical analysis: ANOVA.Rats that explored an OF after the induction of frustration exhibited a faster recovery from this situation.This effect was block by the administration of antagonists of the cholinergic and adrenergic system. The present results consolidate the notion that exposure to novelty represents a simple, yet valuable behavioral treatment for recovery from incentive loss.