INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
BRIEF PERINATAL EXPERIENCES WITH ETHANOL INTOXICATION MODIFY RESPIRATORY AND THERMOREGULATORY PLASTICITY AND AFFECT SUBSEQUENT ETHANOL INTAKE PATTERNS IN RATS
Autor/es:
ACEVEDO, M.B.; ANUNZIATA, F; HAYMAL, O.B.; MACCHIONE, A.F.; MOLINA, J.C.
Lugar:
Valencia
Reunión:
Congreso; 15th European Society on Biomedical Research on Alcoholism; 2015
Institución organizadora:
European Society on Biomedical Research on Alcoholism
Resumen:
Prior studies indicate that perinates develop conditioned breathing depressionmediated by ethanol?s toxic effects upon the respiratory system.Stimuli paired with the disruptive respiratory effects of the drug,later elicit isodirectional effects relative to the ones originally elicitedby the state of intoxication. In this study we utilized an animalmodel that, in terms of brain development, mimics the main characteristicsof the 3rd human gestational trimester. Different goals were pursued:a) the analysis of respiratory and thermal consequences ofsequential exposure to ethanol (0.0 or 3.0 g/kg, i.g., postnatal days3, 5 and 7) upon later effects (postnatal day 9) of different ethanoldoses (0.0, 0.75, 1.5 or 3.0 g/kg) and b) the consequences of earlyethanol sequential ethanol exposure upon infantile alcohol drinkingpatterns (postnatal days 11 and 12). The results indicated that sequentialethanol exposure leads to a conditioned breathing depressionprobably regulated by contextual cues. This responsewas independentfrom thermal changes at test and was only observable in pups with aninitial heightened sensitivity to ethanol?s depressant effects upon respiration.Interestingly, when pups were evaluated in terms of alcoholdrinking, there was evidence of a conditioned thermal response (hypothermia)that generated subsequent aversions to ethanol. Overall, thestudy indicates the existence of multiple learning effects comprising respiratoryand thermoregulatory patterns of the developing organismthat can also impact upon subsequent ethanol intake patterns