"Hydroelectrolyte balance: the right neuronal activity in the right moment".

A. GODINO

Simposio; . III Symposium Miguel Ozorio de Almeida (SMOA); 2015

Changes in body water/sodium balance are tightly controlled to avoid an abnormal cardiovascular function and develop pathological states. The central nervous system (CNS) receives and process the information regarding to the status of body sodium and water. The sensory integration takes place in different nuclei, with diverse phenotype and at different levels of the CNS. We will discuss our evidence showing in this network the involvement of specific neurochemical circuits regulating different disturbances of body water/ sodium balance and fetal programming during an early ethanol exposure.We analyzed how the body sodium levels modulate the serotonergic central system. In this way, sodium depletion and sodium overload decrease and increase respectively the activity of serotonergic cells. These changes of serotonergic neurons activity and serotonergic mechanisms are involved in the manifestation of sodium appetite behavior, promoting a fluid homeostasis reestablishment when hydroelectrolyte balance is disturbed. Besides, our data indicate that prenatal ethanol exposure alters hydroelectrolyte balance and increases the serotonergic neural activity of raphe system, as shown by Fra like expression, in the adolescent offspring.In summary, our results indicate the serotonergic circuit?s involvement in hydroelectrolyte homeostasis regulation in normal as well as in early ethanol exposure rats.