Ethanol Consumption in Adolescents Rats Resulting from Selectively Bred, High and Low Ethanol Consumers, Lines

MACARENA FERNÁNDEZ; BÁEZ B; ESPINOSA, L.; BORDÓN A; MARTÍNEZ, E.; FABIO M.C.; PAUTASSI R.M.

Mar del Plata

Congreso; 30ª Reunión Anual de la Sociedad Argentina de Investigaciones en Neurociencias; 2015

Sociedad Argentina de Investigaciones en Neurociencias (SAN)

We aimed to generate two lines of Wistar rats with high or low predisposition for ethanol intake, by selective breeding of high and low ethanol consumers during adolescence, a developmental stage in which ethanol use disorders emerge and are likely determined.These lines should be a valuable tool to analyze the relationship between motivational sensitivity to ethanol and ethanol intake during the initial generations. In this study, we present data of ethanol intake and its preference of the first two generations derived from our short-term selection process. Results indicated that in F1 generation, ethanol intakewas significantly greater in High Alcohol Consumers (HAC) than in Low Alcohol Consumers (LAC) animals. Visual inspection of the data from F2 generation suggests a similar pattern of intake as observed in F1 generation, but differences between HAC and LAC intake patterns did not attach significance. These results suggest a rapid emergence of differences in ethanol intake following a short-term selective breeding that takes into account theexpression of this variable within a short time frame of development (i.e., adolescence).Even we were not able to observe differences in ethanol intake between HAC and LAC animals of F2, this model provides a useful tool for the analysis of behavioral and neural determinants of alcohol intake trajectories.