?Hydroelectrolytic homeostatic responses: maternal/perinatal influences on vasopressin system?,

VIVAS L

Aguas de Lindoia, San Pablo, Brasil.

Congreso; L Congress of the Brazilian Society of Physiology; 2015

Sociedad Brasilera de Fisiologia

Osmoregulatory mechanisms can be vulnerable to perinatal electrolyte environmental changes, differentially programming the developing offspring and affecting them even in adulthood. The aim of our study was to evaluate whether perinatal availability of hypertonic sodium solution [PM-Na] from the pregnancy until one month old of the offspring may induce a differential programming of osmoregulatory mechanisms in adult offspring. We have studied the perinatal manipulation [PM] effects on adult water/sodium intake, brain cell activity and gene expression changes induced by different osmotic challenges: acute sodium depletion (ASD) and systemic sodium overload (SSO). After ASD we observed an altered pattern of fluid intake in PM-Na adults. At brain level, ASD induced an increased number of activated cells in subfornical organ (SFO) and vasopressinergic neurons of supraoptic nucleus (SON) and a decreased number of them in the solitary tract nucleus (NTS) of PM-Na rats. After SSO, water intake of PM-Na rats was increased and SFO and NTS neural activity was decreased in comparison to control groups. Besides, real-time PCR studies showed a diminished mRNA expression of vasopressin in SON and AT1a receptor in SFO, respect to controls. Perinatal sodium availability induces a long term effect on adult offspring fluid drinking and brain activity/gene expression suggesting the existence of osmosensitive system neuroadaptive response.