INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Sex chromosome complement effect on sexually dimorphic brain angiotensin receptors expression
Autor/es:
DADAM FLORENCIA MARIA; ANDRE GODINO; ANA FABIOLA MACCHIONE; MARIA JULIA CAMBIASSO; LAURA VIVAS; XIMENA CAEIRO
Lugar:
Foz do Iguazu
Reunión:
Congreso; PANAM - 1 ST PANAMERICAN CONGRESS OF PHYSIOLOGICAL SCIENCES - PHYSIOLOGY WITHOUT BORDERS; 2014
Resumen:
The aim of this study was to define whether sex chromosome complement (SCC) may differentially modulate sex differences of mRNA brain expression of the Ang II and Ang-(1-7) receptors. For this purpose, we used the "four core genotypes" mouse model, in which the effect of gonadal sex and SCC is dissociated, allowing comparisons of sexually dimorphic traits between XX and XY females as well as in XX and XY males. Brains were collected from gonadectomized male (XX and XY) and female (XX and XY) mice and brain relative gene expression of AT1aR, AT2R, and MasR receptors were assessed using quantitative real time-PCR (n=6). Statistical analysis of the Subfornical Organ (SFO) data showed that, regardless of gonadal status, XY-SCC mice showed a greater AT1aR expression vs. those with XX-SCC {F(1,20)=4.38; p