INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effects of prenatal ethanol experience upon maternal metabolism and pup/dam interactions during breastfeeding
Autor/es:
PUETA M; ABATE P; HAYMAL OB; SPEAR NE; MOLINA JC
Lugar:
Chicago, Illinois, EEUU
Reunión:
Congreso; 30th Annual Meeting of the Research Society on Alcoholism; 2007
Institución organizadora:
Research Society on Alcoholism
Resumen:
Female rats show severe disruptions in maternal care when administered with EtOH. These disruptions are not observed when dams have been previously exposed to the drug during late gestation. Two experiments were conducted to evaluate possible metabolic changes resulting from EtOH exposure during late pregnancy that can mitigate subsequent behavioral alterations during breastfeeding. The impact of ethanol exposure during gestation and nursing was also evaluated in terms of infantile nursing processes. In both experiments pregnant rats were treated with EtOH (1 or 2 g/kg, i.g.) or water during gestational days 17 – 20 and latter challenged (postnatal day 3) with a subnarcoleptic EtOH dose (2.5 g/kg, i.g.). In Experiment 1, maternal BECs were assessed at PD 3 at 5, 15, 30, 75, 120 and 240 min. postadministration times. Prenatal experiences with EtOH were found not to affect pharmacokinetic processes during early nursing. Experiment 2 examined the impact of EtOH exposure during late gestation upon infantile milk intake in a nursing bout defi ned by the context of maternal EtOH intoxication. All dams received a 2.5 g/kg EtOH dose and pups were allowed to suckle from their mother for a 45-min interval. Pups that suckled from a dam with prior EtOH experience gained signifi cantly more weight than did infants suckling from an intoxicated mother that received water during gestation. The latter pups practically showed no body weight gains.                                                                                                                                                          These results indicate that behavioral tolerance to EtOH in dams exposed to the drug during late gestation is not dependent upon metabolic changes. The results also indicate that EtOH intoxication during the breastfeeding period has a deleterious effect upon infantile nursing processes which is partially reversed when dams have previously experienced the drug. Apparently, late gestational experience with EtOH results in subsequent behavioral or physiological development of ethanol tolerance which permits availability of milk contaminated with ethanol or resistance to the drug’s disruptions in maternal care.