INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
LPBN SEROTONERGIC SYSTEM INVOLMENT IN SODIUM APPETITE DELAY
Autor/es:
A. GODINO; LISANDRA OLIVEIRA MARGATHO; GEAN DOMINGOS DA SILVA; ANTUNES-RODRIGUES J.; L. VIVAS
Reunión:
Congreso; 1 Panamerican congress of physiological Sciences; 2014
Resumen:
LPBN SEROTONERGIC SYSTEM INVOLMENT IN SODIUM APPETITE DELAY The aim of the present work was to analyze the participation of serotonergic brainstem system in the temporal dissociation between sodium depletion (SD) and the appearance of sodium appetite (SA) behavior, particularly, 2h after SD when the rats are hypovolemic/natremic but SA is not evident. We investigated the effects of bilateral injections of serotonin (5-HT) receptor antagonist Methysergide into the LPBN on hypertonic NaCl and water intake at 2h vs 24h after SD. Bilateral LPBN injections of the serotonergic 5-HT1/2 receptor antagonist methysergide (4 μg/200 nl at each site) increased hypertonic NaCl intake when tested 2 and 24 h after SD (time after SD X LPBN injection X repeated measured; F3,78=13,85p=0,0000001). Water intake also increased after bilateral injections of methysergide into the LPBN 24h after SD in compared with vehicule and 2h after SD (time after SD X LPBN injection; F1, 26= 12,98; p=0,00130). In summary, these results show that serotonergic mechanisms in the LPBN modulate sodium intake during the delay of sodium appetite, and it is in part responsible for the temporal dissociation between sodium depletion and the behavioral arousal.