“Brain neuro-chemical pathways involved in hydroelectrolyte and cardiovascular balance”,

LAURA VIVAS, XIMENA CAEIRO, ANDREA GODINO.

Buenos Aires

Simposio; XXII Latin-American and First Ibero-American Congress of Physiological Sciences (IBERO-ALACF),; 2006

Brain neuro-chemical pathways involved in hydroelectrolyte and cardiovascular balance. Laura Vivas, Ximena Caeiro, Andrea Godino. Laboratorio de Homeostasis hidrosalina. Instituto de Investigación Médica M. y M. Ferreyra, Córdoba, Argentina.   This talk will discuss some recent experimental evidence about the role of the endogenous β-endorphinergic system on blood pressure regulation during dietary sodium overload, employing a β-endorphin-deficient mouse line with gene dosage–dependent variations in brain β-endorphin, expressing either 100%, 50%, or 0% of normal β-endorphin content. Besides, in the talk it will be analysed new data regarding the involvement of the serotonergic and oxytocinergic systems in sodium appetite regulation. In sodium depleted animals consuming sodium salts in order to restore body sodium balance it will be examined the activation of the serotonergic and oxytocinergic neurons, (by means of double immunohistochemical detection) in order to discriminate whether the activation of these neurochemical brain groups it might be considered a consequence of sodium satiation process or may be the result of either orosensory stimulation produced by 2% NaCl, or the postingestive consequences such as, stimulation of gastric, hepatoportal sodium sensors.   Supported by CONICET, ANPCyT.