ProBDNF Biology and Emerging Roles in the CNS: The Unexpected Journey of Proneurotrophins

MARGARITA ARANGO-LIEVANO; AGUSTÍN ANASTASÍA GONZALEZ; FREDDY JEANNETEAU

Brain-Derived Neurotrophic Factor (BDNF): Therapeutic Approaches, Role in Neuronal Development and Effects on Cognitive Health

Nova Science Publishers

Año: 2015; p. 1 - 150

This book examines the latest research in brain-derived neurotrophic factor (BDNF) in Huntington´s Disease, in the treatment of diminished glutamatergic signaling in schizophrenia; its role in cognition and treatment response; its importance in the normal course of brain development in which abnormal BDNF expression during critical developmental periods has been increasingly linked to autistic pathology; and finally, a review of proBDNF intracellular and extracellular processing, transport, signaling mechanisms as well as its biological function in health and disease. (Imprint: Nova Biomedical)