INIMEC - CONICET 05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
Amitriptyline Treatment Under Chronic Stress Conditions: Effect on Circulating Catecholamines and Anxiety in Early Maternally Separated Rats
Autor/es:
COTELLA, EVELIN M., MESTRES LASCANO, IVÁN, LEVIN, GLORIA M., SUÁREZ, MARTA M.
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2009 vol. 119 p. 664 - 680
ISSN:
0020-7454
Resumen:
The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.
