INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
Naloxone and baclofen attenuate ethanols locomotor-activating effects in preweanling Sprague-Dawley rats.
Autor/es:
ARIAS, C.; MLEWSKI E.C.; MOLINA, JC; SPEAR, NE
Revista:
BEHAVIORAL NEUROSCIENCE.
Editorial:
AMER PSYCHOLOGICAL ASSOC
Referencias:
Año: 2009 vol. 123 p. 172 - 189
ISSN:
0735-7044
Resumen:
Heterogeneous rat strains appear to be particularly sensitive to the
sedative effects of ethanol as adults and insensitive to ethanol's
stimulant effects. Recently, the authors found that ethanol induces
stimulant effects in preweanling Sprague-Dawley rats. In adult mice,
these effects seem to be governed by the mesocorticolimbic dopaminergic
pathway, which can be modulated by means of GABA B agonist (baclofen) or
opioid antagonist (naloxone) treatments. This study tested whether
these pharmacological treatments might reduce the activating effect of
ethanol in preweanling Sprague-Dawley rats. Twelve-day-old pups given
naloxone (Experiment 1A) or baclofen (Experiment 1B) before ethanol
administration were tested in terms of locomotor activity in a novel
environment. Naloxone and baclofen significantly reduced the stimulating
effect of ethanol but had no effect on locomotor activity patterns in
water-treated controls. Blood ethanol levels were not affected by
naloxone or baclofen (Experiment 2). During the preweanling period,
opioid and GABA B receptors seem to be involved in the stimulating
effect of ethanol.