INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
Changes in Hippocampal Arc Protein Expression and Synaptic Plasticity by
Autor/es:
MONTI MARIA CAROLINA; ALMIRON ROMINA SOLEDAD; BIGNANTE ELENA ANAHI; RAMIREZ OSCAR
Revista:
SYNAPSE
Editorial:
Wiley-Liss
Referencias:
Año: 2010 p. 39 - 46
ISSN:
0887-4476
Resumen:
ABSTRACT Contextual cues linked to drug experience have been frequently associated
to craving and relapse, with this phenomenon being described in human and
experimental animals. Hippocampal synaptic plasticity has been related to learning,
memory, and adaptive processes developed during chronic administration of drug
abuse. In this study, we investigated if the environmental context associated with
withdrawal experience was able to evoke the same behavioral alteration observed
after chronic benzodiazepine administration. Furthermore, we studied the hippocampal
synaptic plasticity and anatomical expression of Arc protein during withdrawal
and the re-exposure to the context associated with anxiety expression (characteristic
sign of benzodiazepines withdrawal). It was demonstrated that re-exposure evoked on
to craving and relapse, with this phenomenon being described in human and
experimental animals. Hippocampal synaptic plasticity has been related to learning,
memory, and adaptive processes developed during chronic administration of drug
abuse. In this study, we investigated if the environmental context associated with
withdrawal experience was able to evoke the same behavioral alteration observed
after chronic benzodiazepine administration. Furthermore, we studied the hippocampal
synaptic plasticity and anatomical expression of Arc protein during withdrawal
and the re-exposure to the context associated with anxiety expression (characteristic
sign of benzodiazepines withdrawal). It was demonstrated that re-exposure evoked on
to craving and relapse, with this phenomenon being described in human and
experimental animals. Hippocampal synaptic plasticity has been related to learning,
memory, and adaptive processes developed during chronic administration of drug
abuse. In this study, we investigated if the environmental context associated with
withdrawal experience was able to evoke the same behavioral alteration observed
after chronic benzodiazepine administration. Furthermore, we studied the hippocampal
synaptic plasticity and anatomical expression of Arc protein during withdrawal
and the re-exposure to the context associated with anxiety expression (characteristic
sign of benzodiazepines withdrawal). It was demonstrated that re-exposure evoked on
to craving and relapse, with this phenomenon being described in human and
experimental animals. Hippocampal synaptic plasticity has been related to learning,
memory, and adaptive processes developed during chronic administration of drug
abuse. In this study, we investigated if the environmental context associated with
withdrawal experience was able to evoke the same behavioral alteration observed
after chronic benzodiazepine administration. Furthermore, we studied the hippocampal
synaptic plasticity and anatomical expression of Arc protein during withdrawal
and the re-exposure to the context associated with anxiety expression (characteristic
sign of benzodiazepines withdrawal). It was demonstrated that re-exposure evoked on
Contextual cues linked to drug experience have been frequently associated
to craving and relapse, with this phenomenon being described in human and
experimental animals. Hippocampal synaptic plasticity has been related to learning,
memory, and adaptive processes developed during chronic administration of drug
abuse. In this study, we investigated if the environmental context associated with
withdrawal experience was able to evoke the same behavioral alteration observed
after chronic benzodiazepine administration. Furthermore, we studied the hippocampal
synaptic plasticity and anatomical expression of Arc protein during withdrawal
and the re-exposure to the context associated with anxiety expression (characteristic
sign of benzodiazepines withdrawal). It was demonstrated that re-exposure evoked on
days 15 and 25 after the first exposure the same behavior. An increased hippocampal
synaptic plasticity, expressed as the threshold to induce long-term potentiation on dentate
gyrus, was observed in animals dependent on diazepam and during retrieval, in
synaptic plasticity, expressed as the threshold to induce long-term potentiation on dentate
gyrus, was observed in animals dependent on diazepam and during retrieval, in
synaptic plasticity, expressed as the threshold to induce long-term potentiation on dentate
gyrus, was observed in animals dependent on diazepam and during retrieval, in
synaptic plasticity, expressed as the threshold to induce long-term potentiation on dentate
gyrus, was observed in animals dependent on diazepam and during retrieval, in
days 15 and 25 after the first exposure the same behavior. An increased hippocampal
synaptic plasticity, expressed as the threshold to induce long-term potentiation on dentate
gyrus, was observed in animals dependent on diazepam and during retrieval, in
the same group, until day 15. This plastic change disappeared 25 days after the first
exposure. An overexpression of Arc protein in the dorsal dentate gyrus and CA1 during
the first day, in absence of drug, after chronic diazepam treatment, in the depend
exposure. An overexpression of Arc protein in the dorsal dentate gyrus and CA1 during
the first day, in absence of drug, after chronic diazepam treatment, in the depend
exposure. An overexpression of Arc protein in the dorsal dentate gyrus and CA1 during
the first day, in absence of drug, after chronic diazepam treatment, in the depend
exposure. An overexpression of Arc protein in the dorsal dentate gyrus and CA1 during
the first day, in absence of drug, after chronic diazepam treatment, in the depend
the same group, until day 15. This plastic change disappeared 25 days after the first
exposure. An overexpression of Arc protein in the dorsal dentate gyrus and CA1 during
the first day, in absence of drug, after chronic diazepam treatment, in the depend
ent animals was observed.