INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake.
Autor/es:
DALMASSO, C. .; ANTUNES-RODRIGUES, J; VIVAS, L.; DE LUCA, L.A
Revista:
PHYSIOLOGY AND BEHAVIOR
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 151 p. 494 - 501
ISSN:
0031-9384
Resumen:
Water deprivation (WD) followed by water intake to satiety, produces satiation of thirst and partial rehydration(PR). Thus, WD?PR is a natural method to differentiate thirst from sodium appetite. WD?PR also produces Fosimmunoreactivity (Fos-ir) in interconnected areas of a brain circuit postulated to subserve sodium appetite.In the present work, we evaluated the effect of sodium intake on Fos-ir produced by WD?PR in brain areasoperationally defined according to the literature as either facilitatory or inhibitory to sodium intake. Isotonic NaClwas available for ingestion in a sodium appetite test performed immediately after a single episode of WD?PR.Sodium intake decreased Fos-ir in facilitatory areas such as the lamina terminalis (particularly subfornical organand median preoptic nucleus), central amygdala and hypothalamic parvocellular paraventricular nucleus in theforebrain. Sodium intake also decreased Fos-ir in inhibitory areas such as the area postrema, lateral parabrachialnucleus and nucleus of the solitary tract in the hindbrain. In contrast, sodium intake further increased Fos-ir thatwas activated by water deprivation in the dorsal raphe nucleus, another inhibitory area localized in the hindbrain.WD?PR increased Fos-ir in the core and shell of the nucleus accumbens. Sodium intake reduced Fos-ir in bothparts of the accumbens. In summary, sodium intake following WD?PR reduced Fos-ir in most facilitatory andinhibitory areas, but increased Fos-ir in another inhibitory area. It also reduced Fos-ir in a reward area (accumbens).The results suggest a functional link between sodium intake and the activity of the hindbrain?forebrain circuitrysubserving reward and sodium appetite in response to water deprivation.