INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
A Potent Combination Microbicide that Targets SHIV-RT, HSV-2 and HPV
Autor/es:
KIZIMA L; RODRÍGUEZ A; KENNEY J; DERBY N; MIZENINA O; MENON R; SEIDOR S; ZHANG S; LEVENDOSKY K; JEAN-PIERRE N; PUGACH P; VILLEGAS G; FORD BE; GETTIE A; BLANCHARD J; PIATAK M JR; LIFSON JD; PAGLINI G; TELESHOVA N; ZYDOWSKY TM; ROBBIANI M.; FERNÁNDEZ-ROMERO JA
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2014 vol. 9 p. 94547 - 94547
ISSN:
1932-6203
Resumen:
Prevalent infection with human herpes simplex 2 (HSV-2) or human papillomavirus (HPV) is associated with increased human immunodeficiency virus (HIV) acquisition. Microbicides that target HIV as well as these sexually transmitted infections (STIs) may more effectively limit HIV incidence. Previously, we showed that a microbicide gel (MZC) containing MIV-150, zinc acetate (ZA) and carrageenan (CG) protected macaques against simian-human immunodeficiency virus (SHIV-RT) infection and that a ZC gel protected mice against HSV-2 infection. Here we evaluated a modified MZC gel (containing different buffers, co-solvents, and preservatives suitable for clinical testing) against both vaginal and rectal challenge of animals with SHIV-RT, HSV-2 or HPV. MZC was stable and safe in vitro (cell viability and monolayer integrity) and in vivo (histology). MZC protected macaques against vaginal (p