INIMEC - CONICET 05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
The role of small GTPases in neuronal morphogenesis and polarity.
Autor/es:
CHRISTIAN GONZALEZ-BILLAULT; PABLO MUÑOZ-LLANCAO; DANIEL R. HENRIQUEZ; JOSÉ WOJNACKI; CECILIA CONDE; ALFREDO CÁCERES
Revista:
Cytoskeleton
Editorial:
Willey Online Library
Referencias:
Lugar: New York; Año: 2012 vol. 69 p. 464 - 485
ISSN:
1949-3592
Resumen:
The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation.
