INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
IQGAP1: a microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity
Autor/es:
JAUSORO I; MESTRES I; REMEDI MM; SANCHEZ M; CACERES A
Revista:
HISTOLOGY AND HISTOPATHOLOGY
Editorial:
F HERNANDEZ
Referencias:
Lugar: Madrid; Año: 2012
ISSN:
0213-3911
Resumen:
In this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with  cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.