INIMEC - CONICET   05467
INSTITUTO DE INVESTIGACION MEDICA MERCEDES Y MARTIN FERREYRA
Unidad Ejecutora - UE
artículos
Título:
Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats.
Autor/es:
ARIAS, C.; SOLARI, AC; MLEWSKI E.C.; MILLER, S.S.; HAYMAL, OB; SPEAR, N.E.; MOLINA, JC
Revista:
BEHAVIOURAL BRAIN RESEARCH
Editorial:
Elsevier
Referencias:
Año: 2010 vol. 211 p. 64 - 70
ISSN:
0166-4328
Resumen:
Preweanling rats are highly sensitive to the locomotor stimulation
induced by relatively high ethanol doses. In adult mice this ethanol
effect is modulated by stress. The goal of the present study was to
analyze the role of stress and corticosterone in the stimulating effect
of ethanol in preweanling rats. In Experiment 1 15-day-old rats were
separated from the mother during a period of 4 h in which subjects
remained isolated or paired with a littermate. In a third condition pups
remained in the home-cage with the dam. After this isolation period
pups were given ethanol (0 or 2.5 g/kg) and were tested in a novel
environment. Previous data have shown that a similar period of isolation
is enough to increase corticosterone levels in preweanling rats.
Experiment 2 evaluated the effect of exogenous administration of
corticosterone (0, 3 or 6 mg/kg) along with ethanol, and Experiment 3
tested ethanol-mediated locomotor activation in adrenalectomized
preweanling rats. The last experiment aimed to test the role of
corticotropic releasing factor 1 (CRF1) receptors in locomotion induced
by ethanol in isolated pups. According to our results there is a
synergism between stress or corticosterone and ethanol in preweanling
rats. The interaction between stress (induced by social isolation) and
ethanol seems to be mediated by CRF, since blockade of CRF1 receptors
cancelled the effect of ethanol in isolated pups. This study highlights
the importance of considering stress as a possible intervening variable
in studies evaluating ethanol effects in developing animals when
maternal separation is used in the experimental procedure.