INIQUI   05448
INSTITUTO DE INVESTIGACIONES PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Amphotericin B release from polymeric films. Modeling and pharmaceutical parameters determination.
Autor/es:
PISTÁN, FLORENCIA ALEJANDRA; BRIONES, CINTIA ALEJANDRA; BERMUDEZ, JOSÉ MARÍA; VILLEGAS, MERCEDES; GONZO, ELIO EMILIO; ROMERO, ANALIA IRMA; CID, ALICIA GRACIELA
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Anual de Sociedades de Biociencia - SAIC - SAFE - SAB ? SAP ? AACYTAL - NANOMED-ar ? HCS; 2019
Resumen:
Leishmaniasis is a "neglected" endemic disease and is a priority public health problem for Salta and Argentina. Treatment currently available in our country is very painful and invasive. Particularly for cutaneous leishmaniasis, there is no topical/local treatment that meets the activity, safety and cost requirements. For this reason, polymeric films with an appropriate drug load are proposed as alternative systems. Two polymers were selected, one of natural origin, sodium alginate (SA), and one synthetic, carbomer (CB). Amphotericin B (AnB) was used as a specific drug for the leishmaniasis treatment. The films were prepared with different drug concentrations using only SA or a combination of SA and CB.The cross section of the films was observed by scanning electron microscopy (SEM) and the in-vitro release assays were performed at 37°C. The release profiles were analyzed and adjusted using the Lumped model developed and validated by our research group. Pharmaceutical interest parameters were calculated: t80% is the time required to reach 80% dissolution of the total drug available, the Dissolution Efficiency (DE) is defined as the area under the dissolution profile up to a certain time, and the Average Dissolution Time (ADT) provides information about the ability of the polymer platform to delay the drug release.SEM images showed that films loaded with AnB maintained a dense structure and the drug was evenly distributed throughout the thickness of the film.AnB release profiles revealed that the CB incorporation caused a marked increase in the initial release rate, with a burst drug release in a short period of time, effect that is not suitable for systems that must modulate the drug release.Pharmaceutical relevance parameters were calculated and compared. It was determined that the SA films were able to modulate the drug release rate and presented optimal values of the parameters, in particular the film loaded with the highest percentage of AnB.