Evaluation of novel solid dispersions with thermosensitive Poloxamer 407 as carrier for veterinary use

SIMONAZZI, A; BERMUDEZ, J M; PALMA, S

BUENOS AIRES

Congreso; 6th International Conference on Science and Technology of Composite Materials; 2015

The permeability and solubility of some drugs may be restrictive for oral absorption with a consequent decrease in bioavailability. Solids dispersions (SDs) have been proposed as alternative to improve the dissolution rate of different drugs using carriers like poloxamer. The aim of this work was to evaluate the release profiles in simulated gastric fluid, of new polymeric DSs of Albendazole (ABZ), using Poloxamer 407, a thermosensitive polymer as carrier. Results were compared with a commercial formulation (CF).In all prepared DSs (5, 10, 25 and 50 % w/w ABZ) improved dissolution rate is shown in comparison with CF. For example, SD4 released 70% of ABZ at 10 minutes, while CF only reaches 40%. However, increasing the proportion of poloxamer in the formulations, the release is controlled by the carrier. This effect can be explained because when SDs take contact with the dissolution medium at 37°C, the P407 would form a gel-layer in the particles surface that can be able to modulate the release of ABZ. Physical mixtures (PMs) were prepared in equal proportions to the formulations studied, showing a different behavior to that of the SDs. Since they are mechanical mixtures, ABZ particles could be distributed unevenly in the dissolution medium. The addition of P407 as carrier in SDs containing ABZ markedly improves its dissolution properties compared with a commercial tablet. These promising results allow us to continue developing new antiparasitic formulations for veterinary use.