Evaluation of Albendazolerelease from composite thermosensitive polymeric matrices poloxamer ? chitosan

BERMUDEZ, J. M.; DIB ASHUR PÉREZ, J.; SIMONAZZI, A.; VIRGILI, V.; CID, A. G.

Córdoba

Otro; 3° Reunión Internacional de Ciencias Farmacéuticas -RICiFa 2014; 2014

Apolymer solution capable of gelling in situ at a temperature close to the physiological one might be attractive for the development of drug delivery systems for veterinary use.The scope of the present contribution was to explore the potential of novel thermosensitive drug delivery platforms designed by combination of two different poloxamers (P407 and P188) with chitosan (CH). The release experiments were performed using the membraneless model since this procedure allows direct contact between gel and release medium, and gelerosion can also be considered. In membraneless model, two phenomena are involved: the fickian diffusion of the drug and the dissolution of poloxamer. To asses the influence of the concentration of poloxamer and chitosan in the drug release, gels of P407, P188 and CH in different proportions (formulations 28/12,28/15, 28/12/0.5, 28/12/1, 28/15/0.5 and 28/15/1)% w/w were studied. The viscosity of all formulations was suitable for an injectable administration. The addition of chitosan decreased the release of albendazole from the gels containing 12% of P188, but this effect was less in the gels with 15% of P188. Release data were then processed using the powermodel. The n values obtained were between 0.5 and 1 for all formulations, suggesting that, besides the diffusion mechanism, other mechanisms are involved in the kinetic control of drug release. Therefore, dissolution and relaxation polymer processes could be involved in drug release mechanism. The poloxamer system is one of theswelling-controlled systems, which functions by a process of continuous swelling of the polymer carrier that is associated with simultaneous or later dissolution of the polymer. Depending on the composition of the poloxamer blend, chitosans lowed the albendazole release. This study demonstrates that the addition of chitosan into poloxamers blends can be considered a useful tool to design thermosensitive injectable depot systems, if added in suitable amounts.