Films based on soy protein-agar blends for wound dressing: Effect of different biopolymer proportions on the drug release rate and the physical and antibacterial properties of the films

AUDISIO, M. CARINA; GORUSTOVICH, ALEJANDRO A.; RIVADENEIRA, JOSEFINA

JOURNAL OF BIOMATERIALS APPLICATIONS

SAGE PUBLICATIONS LTD

Lugar: London; Año: 2018 vol. 32 p. 1231 - 1238

0885-3282

No single material can provide all requirements for wound dressings. Here, we evaluated the influence of different soyprotein isolate and agar proportions (3:1, 1:1, and 1:3) in blend films on some of their physical-chemical and antibacterialproperties to elucidate their potential as wound dressings. The films were synthesized by the gel casting method andciprofloxacin hydrochloride was incorporated into the films. Films were characterized based on their surface morphology,water uptake ability, and weight loss profile. Also, the ciprofloxacin hydrochloride release kinetics was quantifiedspectrophotometrically. The antibacterial effect was evaluated against Staphylococcus aureus and Pseudomonas aeruginosastrains. The soy protein isolate-agar ratio affected the water uptake of the films and the release profile of ciprofloxacinhydrochloride but not the weight loss profile. The amount of drug released decreased near 80% because of the decreasein agar content in the films. The release kinetics of ciprofloxacin hydrochloride data best fitted to the Korsmeyer?Peppasmodel, suggesting that the mechanism of drug release was mainly of the diffusion type. All ciprofloxacin hydrochloridereleasingsoy protein isolate-agar films strongly inhibited the cell viability of the bacterial strains studied. We concludedthat water uptake and ciprofloxacin hydrochloride release can be controlled by changing the soy protein isolate-agarproportion. The proportions did not lead to changes in the antibacterial strength of the films