Crystal structure of a lapacholate complex with Co(II), a potential antibacterial pharmaceutical

R. FARFÁN; GÓMEZ, MARÍA INÉS; E.E.CASTELLANO; J. A. ESPÍNDOLA; GÓMEZ, M.I.; M.C.AUDISIO; M.L.BRITOS; O.PIRO

JOURNAL OF MOLECULAR STRUCTURE

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2019 vol. 1180 p. 792 - 797

0022-2860

The solid state molecular structure of dilapacholate diaquo cobalt (II) di-dimethylformamide, for short[Co(Lap)2(H2O)2]$2DMF, was determined by X-ray diffraction methods. It crystallizes in the monoclinicspace group P21/n with Z ¼ 2 molecules per unit cell. The complex is at a crystallographic inversioncentre with the Co (II) ion in a distorted octahedral environment of approximate D2h local symmetry,coordinated to two lapacholate anions acting as bidentate ligands through their carbonyl and phenolicoxygen atoms, and to two water molecules nearly along the bisector of their oxygen electron lone-pairlobes.The IR absorption spectrum, electronic absorption, TGA data and also a comparison of IR characteristicbands with the corresponding ones of other Co-lapacholates are also discussed.At a concentration of 25 ppm, the new metal complex shows biological activity against several clinicalStaphylococcus aureus strains.