MODELING OF PROGESTERONE RELEASE FROM POLY(3-HYDROXYBUTYRATE) (PHB) MEMBRANES

ANALIA I. ROMERO; JOSÉ M. BERMUDEZ; MERCEDES VILLEGAS; FLORENCIA DIB ASHUR; MÓNICA L. PARENTIS; ELIO E. GONZO

AAPS PHARMSCITECH

SPRINGER

Lugar: Berlin; Año: 2015

1530-9932

Poly(3-hydroxybutyrate) (PHB) biodegradable polymeric membranes were evaluated as platform for progesterone (Prg) controlled release. In the design of new drug delivery systems is important to understand the mass transport mechanism involved, as well as predict the kinetics of the process. Drug release experiments were conducted and the experimental results were evaluated using engineering approaches that were extrapolated to the pharmaceutical field by our research group. Membranes were loaded with different Prg concentrations and characterized by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). SEM images showed that membranes have a dense structure before and after the progesterone addition. DSC and FTIR allowed determine the influence of the therapeutic agent in the membrane properties. The in vitro experiments were performed using two different Techniques: A) Returning the sample to the receptor solution (constant volume of the delivery medium) and B) Extracting total volume of the receptor solution. In this work, we present a simple and accurate ?lumped? second order kinetics model. This lumped model considers the different mass transport steps involved in drug release system. The model fit very well the experimental data using any of the two experimental procedures, in the range 0 ≤ t ≤ ∞ or 0 ≤ Mt ≤ M∞. The drug release analysis using our proposed approaches is relevant for establishing in vitro-in vivo correlations in future tests in animals.