CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Beneficial modulation of respiratory immunity by orally administered kefiran
Autor/es:
YANINA KOLLING; SUSANA SALVA; LUCÍA ZAVALA; JULIO VILLENA; PABLO PEREZ; ANALÍA ABRAHAM; SUSANA ALVAREZ
Lugar:
Buenos Aires
Reunión:
Congreso; LXIII Reunión Científica Anual de la Sociedad Argentina de Inmunología (SAI); 2015
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
Background: kefiran is the main exopolysaccharide isolated from kefir grains. Orally administered kefiran induce beneficial changes in the balance of intestinal mucosa immune cells. The aim of this work was to study whether kefiran is able to modulate immunity in the respiratory tract and improve the innate immune response against pneumococcal respiratory infection in mice. Methods: Adult Swiss mice received kefiran (300 mg/L) in the drinking water ad libitum for 2 consecutive days. On day 3, kefiran-treated and untreated control mice were infected nasally with Streptococcus pneumoniae (Sp) (109 UFC/mouse). Systemic and respiratory innate immune responses were evaluated before and after Sp challenge.Results: Kefiran-treated mice showed a significant reduction of lung and blood pneumococcal cell counts counts and lung tissue injuries after the challenge with Sp when compared to the control group (p